Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Teacher training key to democracy and freedom
2011-12-06

 

MEC Mr Tate Makgoe (left) with Faculty of Education’s Prof. Dennis Francis, holding the inaugural SURLEC Award. With them is Dr Dipane Hlalele.
Photo: Thabo Kessah

Universities have the responsibility to respond to the challenges that the South African education system is faced with.

This is the view of the Free State MEC for Education, Mr Tate Makgoe, during his address at the three-day First Sustainable Rural Learning Ecologies (SURLEC) Colloquium, which was recently held at the Qwaqwa Campus of the University of the Free State (UFS).
 
“Our universities must not only research the failures of our system. They must also come up with solutions.
 
“One of the questions that demand answers in our country is whether we produce quality teachers at our universities, considering our learners’ performance internationally. Our children lack the basics like grammar and yet we are 17 years into democracy. Why is their performance so poor in comparison to children in poorer countries?” asked Mr Makgoe.
 
“We must work together as a Government and universities to change this. Universities must be anchors of democracy and freedom, which is meaningless if our children cannot read and write. We must also focus on Mathematics and Natural Sciences, not forgetting to value our indigenous knowledge and games to enhance learning, especially in Mathematics,” he said.
 
According to Dr Dipane Hlalele, Head of the Faculty of Education at the UFS Qwaqwa Campus, the colloquium was held to search for best practices and success stories relating to the theme, Creating sustainable rural learning ecologies in the 21st century.
 
“Our objective was to tap into experiences and wisdom of policy makers, researchers, scholars, teachers and students in order to map a new direction in research as well as to make an indelible mark on the revitalisation of this campus,” concluded Dr Hlalele.
 
The UFS Dean of Education, Prof. Dennis Francis’ efforts to improve rural education were honoured with the first ever SURLEC Award.
 
Over 70 research papers from the universities of the Free State, South Africa, Venda, KwaZulu-Natal, Limpopo and the Cape Peninsula University of Technology were delivered and learners from the local schools like The Beacon, Mafube, Qwaqwa and Clubview presented their winning projects at the Science Expo.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept