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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Little Professors enrol at UFS
2012-01-20

 
Little Professors in the making: Archie Barclay, 3 years, (left) and Khanya Nondabula, 6 years.
Photo: Phelekwa Mpono

About 65 small children have taken up residence at our Bloemfontein Campus, joining the Kovsie family.

The little ones, whose ages range from three months to six years, are the first kids to enrol at The Little Professor Crèche on the campus. The crèche, with its motto Preparing little minds for greatness, opened its doors on 9 January this year.
 
Head of the crèche, Mrs Ricka van Kerkhof, says they received a flood of applications for the 105 available places and forty more kids will be taken in during the coming weeks. Van Kerkhof says the crèche is open to everyone, but preference is given to children of UFS personnel. Currently 90% of the kids are those of university staff.
 
The well-equipped crèche has enough toys to fill up a small shop and offers extramural activities such as piano lessons, swimming, chess and pottery classes. All classes have flat-screen televisions for kids to watch educational programs. The crèche caters for six classes, infants up to Grade R. The Pre-grade R Curriculum and Foundation Phase Grade Curriculum R-3 of the Free State Department of Basic Education are followed. The language of instruction is English and parents who want to enrol their kids will pay R 1150.00 per month.
 
Van Kerkhof, who calls her job the best in the world, says The Little Professor is not a care facility. Rather it’s a place where kids are taught to concentrate on education. “We are teaching kids to be clever.”

 

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