Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New security measures for Rag fundraising
2012-01-25

The University of the Free State will no longer allow first-year students to sell Ritsems or to shake their cans for change at traffic robots in Bloemfontein in an effort to raise funds for Rag Community Service.

This decision follows after an evaluation has been done in 2011 and 2012 concerning the safety risk for students during this type of sales at road crossings.
 
The new security measures have specifically been implemented for this type of sales since last year.
 
The measures included, among others, that students should be obliged to wear brightly coloured safety jackets during sales, continuous supervision of first-year students by senior students to ensure that students keep to the rules of the road, and limiting the sales hours at robots.
 
Through notices in the media, an appeal was made on motorists to keep a lookout for students raising money for Rag Community Service. The measures were implemented and the effects thereof for students’ safety during sales at robots monitored since last year. This follows after a student, Ms Hanje Pistorius, was hit by a reckless driver in 2010 and she subsequently lost her leg as a result of the accident. 
 
Although, from all appearances, the new measures are a positive contribution to protect students even more, the UFS decided to abolish the sales and fund-raising actions at traffic robots. As reckless drivers would not necessarily take notice of the extra measures, the risk to students at robots stay unchanged. 
 
"The UFS sets the safety of its students as first priority and considers it in the best interest of students to not expose first-years to the risk during our Rag programme,” says Mr Rudi Buys, Dean: Student Affairs at the UFS.
 
Night fund-raising and the selling of Ritsem in the city’s suburbs will, however, continue. 
 
Although the UFS do not expect the new measures to be detrimental to fund-raising efforts, Rag Community Service currently considers new supporting proposals for the raising of funds for community projects in order to address any possible reduction in funds. 
 
Mr Buys also has an agreement with Ms Pistorius to assist Rag Community Services in the planning of new projects.
 
The Night fund-raising in suburbs will take place on Tuesday 24 January and Thursday 26 January and the UFS calls on residents to assist students and help them in the important task at hand.
 
Three Rag processions will take place on Saturday 28 January 2012. At 10:00 two Rag procession will be leave for Heidedal and Mangaung, where the Kovsie Rag Community Service will hand out food parcels.
 
The main Rag Procession will leave the UFS at 18:00 and will move towards the Old Greys sports ground for the Rag concert with Die Heuwels Fantasties and DJ Black Coffee.

Media Release
25 January 2012
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept