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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

It's almost time for Rag procession 2012

2012-01-25

This year Rag is bigger and better.

This year’s Kovsie Rag of our universities Bloemfontein Campus promises to stand out head and shoulders above all previous years.

Kovsie Rag and Kovsie Community Service joined hands and is now known as Kovsie Rag Community Service.

For this reason, during this year’s Rag Procession in Heidedal and Mangaung, Kovsie Rag Community Service will distribute food parcels in this community.

The processions in Heidedal and Mangaung will both take place on Saturday 28 January 2012 at 10:00.

In Heidedal participants in the Rag Procession will distribute food parcels at the Twin City Shopping Centre and in Mangaung food parcels will be distributed at the Kenilworth Shopping Centre.

The programme for the Rag Procession is also well underway and first-years are eagerly building floats for this year’s Rag Procession on Saturday 28 January 2012

At 18:00 the main procession will start from the UFS and move to the final destination at Old Greys where DJ Black Coffee and Die Heuwels Fantasties will perform.

For the first time in Rag history, a Mr Rag will this year be crowned together with Miss Rag at the Crowning Ceremony Ball on Friday 3 February 2012.

The purpose of Kovsie Rag Community Service is to raise funds for charity and it is currently the biggest of its kind in South Africa.

“We are in the process of exceeding all expectations” says Pieter Badenhorst, Kovsie Rag officer.

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