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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Always good to be honoured at home, says Justice Richard Goldstone
2012-02-06

 

Justice Richard Goldstone received an honorary doctorate from the university on 3 February 2012.
Photo: Duard Grobbelaar

 

Dumela article (pdf document)
Justice Richard Goldstone's - acceptance speech (pdf document)
Mail & Guardian article (pdf document)

The University of the Free State (UFS) is determined to make a success of its academic and human projects, and is not prepared to compromise on standards in the process.

This was the message of Prof. Jonathan Jansen, Vice-Chancellor and Rector, at our universities official opening on Friday 3 February 2012. These projects, said Prof. Jansen, are the foundation of the institution.

The official opening coincided with an honorary doctorate in Law conferred on Justice Richard Goldstone.

The UFS has enrolled the “smartest and most diverse class since 1904,” Prof. Jansen said.
Top learners with six A’s, and more learners from top schools inside and outside South Africa, have made the UFS their university of choice. “We are determined that the best students must study at Kovsies.”

Prof. Jansen also referred to learners in the school system who sit and wait while teachers fight amongst themselves at the education departments. “What are we going to do with those students?” The UFS provides an opportunity for these students to enter higher education with its University Preparation Programme on its South Campus in Bloemfontein. “The fastest growth at our university is on this campus. It is set aside for children who cannot be taken up in the mainstream.”

Some of the students who were part of this programme are doctors, lawyers and teachers today.

“We set a high standard in our academic project to make sure our students are the best available.”

In its Schools Project, the UFS has 23 schools under its wing and the net is broadening. Pass rates in these schools improved dramatically; in some from 13% to 100% in one year.

The human project sets standards for good behaviour. “I was astounded to see how young people get together to find other people as human beings,” Jansen said. “I have enormous hope for this country.

Some of the other projects he mentioned were the provision of more space for students to study, a refocus on the Qwaqwa Campus in the Eastern Free State, the placement of new academics, and agreements with universities abroad on the placement of young scholars.

After receiving his honorary doctorate, Justice Goldstone congratulated the university on the fact that transformation did not lead to standards being compromised.

“The university now takes its place as a leading university on our continent. The leaders of the university can hold their heads up high about their achievements.”

Judge Goldstone, the bearer of 26 honorary doctorates from various countries around the world, said: “It is always good to be honored at home”.

The official opening was attended by staff, students, guests and community leaders.
 
 

Media Release
3 February 2012
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za
 

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