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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Report card outlines major achievements
2005-02-04

Staff at the University of the Free State (UFS) have received above-inflation increases in remuneration averaging 18,2 percent since the year 2000, according to the Rector and Vice-Chancellor, Prof Frederick Fourie.

Delivering a keynote speech at the Official Opening of the UFS today, Prof Fourie gave a report card for the UFS which he said indicated significant progress in salaries and promotions as well as capital expenditure and infrastructure development on the campus.

“The aggregate extra earnings of staff (money in their pockets above inflation) from 2000 to 2005 amount to R75 million in salaries. This is the result of the hard work of all staff and we pay tribute to them,” he said.

Prof Fourie said that several categories of staff are better off than before the financial turn-around strategy was implemented in 2000 which aimed to make the UFS a financially sustainable campus.

The lowest paid workers and professors had received an additional structural correction, which gave professors at the UFS a 27% above-inflation increase (on total remuneration package) since 2000.

He said there had also been a dramatic increase in promotions to associate professor and full professor during the last 6 years.

From 1999 to December 2001, there were only 9 promotions to associate professor. From January 2002 to January 2005, there were 37 such promotions to associate professor, four times as many.

Regarding promotions to full professor, from 1999 to December 2001 there were 7 promotions. From January 2002 to January 2005, there were 31 promotions to full professor, more than four times as many.

“We have also created a new category of senior professor to give due recognition to the outstanding work of our leading academics in many fields,” Prof Fourie said.

The UFS has introduced numerous new and innovative learning programmes, together with an increasing number of community service modules which enhanced the UFS as a leader in service learning and helped to make it a university engaged with its surrounding community.

According to Prof Fourie the number of support staff had also grown along with the professionalisation of the support services.

He said management was aware that there still several challenges regarding staff overload and staff development but that these were being addressed

Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za

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