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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Faculty of Education discusses new curricula at summit
2012-03-07

 

Die Fakulteit Opvoedkunde se nuut-aangepaste B.Ed.-programme word binnekort by die Nasionale Departement van Hoër Onderwys en Opleiding ingedien vir herakkreditasie. Proff. Rita Niemann (links), Direkteur vir Nagraadse Studie en Navorsing, en Gawie du Toit, Direkteur vir Aanvanklike Onderwysersopvoeding, is aan die stuur van die herkurrikuleringsproses vir voorgraadse en nagraadse programme van die Fakulteit Opvoedkunde.
6 March 2012

The training of professional teachers rests on a strong curriculum. For this reason, the Faculty of Education has been re-looking at the curricula of the B.Ed. programme for the past two years.

Before this programme is submitted for approval and accreditation, the Education Faculty’s staff from the Bloemfontein and Qwaqwa Campuses will attend a summit at the Gariep Dam on 7 and 8 March 2012. This summit is a sequel to guidelines drawn up by the National Department of Higher Education and Training on adjusted requirements for teacher training. It determines that all initial teacher training and honours programmes be recurriculated and resubmitted for accreditation. These requirements were published in the Government Gazette in July 2011 and involve all education faculties in the country.
 
Deans and line heads of other faculties, including Natural and Agricultural Sciences, Humanities, and Economic and Management Sciences, have also become involved as Education students often register for modules in these faculties.
 
Last week a team from the UFS’s Education Faculty also attended a workshop presented by the Council on Higher Education where the criteria for recurriculation and the evaluation of programmes were discussed.
 
Prof. Gawie du Toit of the UFS’s Faculty of Education says curriculation is not merely a technical process but requires thorough reflection and conceptualisation, involving various roleplayers.
“It is important that recurriculation should take place over a period of time to allow for sufficient time for reflection, absorption and ownership.”
 
Thus, the aim of the Gariep Dam summit is to introduce a teachers’ training program that will provide graduates with the necessary knowledge, skills and responsibilities to take up their places as academics and professional beginner teachers.
 
During these two days students in Education will not attend any classes but they are tasked with self study and to complete assignments.

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