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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Intervarsity postponed to 2013
2012-03-08

The annual Intervarsity between the Universities of the Free State and North-West (NWU), which traditionally takes place in the third term, has been postponed to 2013.

The Intervarsity between the UFS and NWU is an illustrious event that has already reached the special milestone of celebrating a 70-year Intervarsity tradition. The UFS/NWU Intervarsity is also known as one of the most reckoned events on the local and national sports and student calendars, and it is widely supported.
 
Representatives from both universities could for a variety of reasons not decide on a date which suited both universities.
 
The respective Intervarsity committees and senior managers of both universities have also taken the interests of the respective university communities and alumni of the institutions into account and have decided to postpone the 70th-year celebration of Intervarsity by a year in order to be able to celebrate the milestone properly.
 
The UFS would have received the NWU in Bloemfontein this year and will therefore host the 70-year celebrations of the event next year as well.
 
Mr Rudi Buys, Dean: Student Affairs at the UFS has expressed his gratitude for the fact that both universities are committed to a special celebration of the Intervarsity tradition in 2013.
 
“The celebration of the 70th Intervarsity between the two institutions will be an important milestone to commemorate decades of friendship, collaboration and healthy competition. Therefore we welcome this opportunity to plan a bigger and better programme for 2013,” he said.
 
The UFS-NWU 70-YEAR Intervarsity firstly aims to establish the programme as a proud example for both universities, where students and staff can pit their strengths against one another in a healthy manner.
 
The aim is to extend Intervarsity to various sections of the respective university communities to enable more students to participate. For instance, more sports codes will be added to the traditional competition on the rugby, soccer, netball and hockey fields, whilst various events focusing on arts and culture, i.e. choral singing and debating competitions, as well as dialogue between student leaders, will take place as part of the programme. All campuses of the two universities will participate in the programmes.
 
Students are even investigating the possibility of electronic competitions such as on-line games as part of the Intervarsity
 
During the Intervarsity last year, several new possibilities were already tested to ensure that the 70th anniversary would be a huge success.
 
The Central Intervarsity Committee of the UFS has decided to replace the Intervarsity 2012 programme with an INTRA-varsity programme between its respective campuses. For this occasion, various sports, arts and culture, and leadership events between the Bloemfontein and Qwaqwa Campuses are planned, and the Central University of Technology might be invited as well to participate as guests in some programmes.

Media Release
8 March 2012
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za


 

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