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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Excellent facilities, pleasant weather and hospitality attract international teams
2012-03-14

 

Germany and South Africa played friendly practice matches at the UFS during their training camps.
Photo: Johan Roux
14 March 2012

Three international hockey teams have used the practice facilities of the university since the beginning of the year to prepare for the Olympic Games in August this year. The German and South African hockey teams have practiced here on four previous occasions.

Due to the cold weather in Europe, Austria also held its hockey training camp at the university this year. In addition, four of Austria’s triathlon athletes used the cross country track and swimming pool on the Bloemfontein Campus to prepare for the Olympic Games.

Germany’s national hockey team practised at the university from 3 to 12 March 2012. South Africa made use of the facilities from 5 to 10 March and Austria’s national team has been practicing in Bloemfontein since 24 February. From 3 to 10 March, a club team from Austria also made use of the university’s facilities, including the astros, the swimming pool, the athletics track and the Biokinetics Centre. SV Arminem also played two matches against the men’s hockey team from Kovsies. The first match end 2-2. With the second match Kovsies won 4-1.

Other international hockey teams who have made use of the astros over the past six years include Russia, Argentina, Belgium, China, Azerbaidjan and the Netherlands.

Staff ensured that everything ran like clockwork during the different training camps. Ms Annemarie Ludick and Mr Frans van der Watt, under the guidance of Mr Mickey Gordon, Head: Institutional Promotion, Fundraising, Marketing and Sport, were responsible for the logistical arrangements and finances. Mr Johan Gerber saw to the maintenance of the astros. The university boasts some of the best equipped astros in the world. “Germany, for example, did not bring along any exercise balls, cones, or beds (for use by physiotherapists) because the astros are fully equipped,” said Ms Ludick.

The fact that international teams such as Germany (ranked second in the world), South Africa and Austria made use of the university’s facilities is significant. “The university’s first team got for example the opportunity to play practice games against these players. The training camps also contributed to the economy of Bloemfontein,” said Ms Ludick.

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