Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

ANC Centenary Seminar looks at the role of women in the liberation struggle
2012-03-22

 

At the ANC Centenary Seminar were, from the left: Nadine Lake, ProgrammeDirector: Gender Studies, at the UFS; Prof. Hassim; Zubeida Jaffer, Writer-in-Residence at the UFS; and Senovia Welman from the UFS-Sasol Library.
Photo: Amanda Tongha
22 March 2012


SAFM Podcast:

Podcast 1
Podcast 2
Podcast 3
Podcast 4

Looking back at the history of South African politics you will always find women involved in that history.”

This is according to Prof. Shireen Hassim, a professor in Political Studies at the University of the Witwatersrand, who recently spoke at an ANC Centenary Seminar, held on the Bloemfontein Campus of the University of the Free State (UFS). The seminar is part of a series of dialogues hosted by the Centre for Africa Studies about the ruling party’s 100 years of existence. It was the first one to be held following the 100 year celebrations of the ANC in January 2012 and was dedicated to the ANC Women’s League. Prof. Hassim told the audience that from early roles as wives who provided catering and entertainment, women have always been politically active in the African National Congress (ANC).

Women took the lead in the defiance campaign, going beyond the role of tea lady of the 1910s. When the ANC went into exile, the women’s section, as it was called then, played an important role.” Prof. Hassim also praised independent women’s organisations for the role they had played during the struggle and added that they were part of the collective history.

Talking about today’s Women’s League, Prof. Hassim said there had been debate about its current role with some critics labelling the league conservative. “In recent years, they have become very allied to internal battles.”

According to Prof. Hassim, a new language was needed that could give voice to the policies that needed to be developed.She drew attention to the plight of rural women, saying that thus far urban women have been taking the lead in defining issues. She warned that legislation like the Traditional Courts Bill would put rural women at a disadvantage. Prof. Hassim said the Bill was not rigorously debated, despite the high number of women in Parliament.

 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept