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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

‘Language central to multidisciplinary society’
2012-03-22

 

Dr. Neville Alexander (right) discussed the role of language and culture in creating tolerance in South Africa. On the left is Prof. André Keet, Director of the UFS' International Institute for Studies in Race, Reconcilliation and Social Justice.
Photo: Johan Roux
22 March 2012

A multilingual state and culture could lead to more tolerance in South Africa, and schools and universities could play a leading role in the creation of a multilingual culture.

This is according to Dr Neville Alexander, one of South Africa’s foremost linguists and educationalists.

Dr Alexander spoke during a discussion session on language issues in a new South Africa at the University of the Free State’s (UFS) International Institute for Studies in Race, Reconciliation and Social Justice.

He said in a multidisciplinary society, language is central to everything we do. 

“Language has the ability to empower people or to disempower them. Yet the present government failed to value the other official South African languages, apart from Afrikaans and English.”

Dr Alexander said it is “convenient and cheap” for the government “to only govern in English”.

Government officials and academics often used the shortage of terminology and glossaries in various African languages as an excuse to use only English as the medium of instruction. This tendency puts young children in the South African school system at a disadvantage since it deprives them of their right to mother tongue education.

According to Dr Alexander, this is similar to the problems that academics experienced centuries ago when only Latin terminology existed for certain disciplines.

“It is the task of educationalists and experts to develop the necessary word lists and terminology to offer more economic value to all our official languages.”

If multilingualism was promoted at school level, a multilingual culture would become more acceptable in future. In this way, we could have an isiZulu of isiXhosa dominant university in South Africa in 30 years time.
 

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