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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Students selected for prestigious Stanford Sophomore College
2012-04-04

 

From the left are: Elri Marais, Palesa Mafisa, Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS, Goodwill Shelile and Foster Lubbe. Gabriela Schroder and Saeed Abdullah were absent when the photo was taken.
Photo: Hannes Pieterse
4 April 2012


As part of the University of the Free State’s (UFS) comprehensive suite of student leadership development programmes, a strategic partnership with Stanford University, USA has been forged.

Starting in 2012, selected cohorts of high-potential second-year students will annually participate in the Stanford Sophomore College Programme. The UFS and Oxford University in the UK are the only non-Stanford participants in this strategic and unique opportunity.

Following a highly competitive selection process based on both written and oral assessment, managed by the UFS Centre for Teaching and Learning and the Office of the Vice-Chancellor, the first group of six students was recently selected and will visit Stanford University from 1 – 14 September 2012.

The exclusive and high profile Sophomore College has been offered at the prestigious Stanford University on the West Coast of the US for a number of years. It takes the form of a residential summer programme for second-year students who participate and engage in intense academic exploration with peers and professors on a variety of innovative, multidisciplinary topics.

Depending on the course selected, students participate in a variety of intellectual and academic programmes, do research, work in labs, engage in readings of texts and develop presentation skills.

Some courses are held in part or entirely off campus. Advisory sessions to assist students in their preparation, academic orientation and intellectual development will be conducted prior to their departure to add value to the experience at Stanford.

The students will benefit from the programme in many ways, among others the intense academic exploration of topics with an eminent international scholar, immersion in and exploration of a field of interest, the opportunity to hone critical habits of mind, train to become a more engaged and entrepreneurial learners and collaborate and form relationships with friends and peers.
 

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