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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New building for Centre for Financial Planning Law
2012-04-23

 

A graphic illustration of the new building for the Centre for Financial Planning Law.
19 April 2012

 

During a recent tree planting ceremony, the Centre for Financial Planning Law in the Faculty of Law officially handed over the site for a new building for the centre. The building should be complete by the end of 2012.

The Centre for Financial Planning Law’s present premises has become too small for the needs of the centre, thus a decision was taken to build a new building.

The centre, which was opened in 2001 with three staff members, grew during the past 11 years to a centre with 13 permanent staff members. Some 1 300 students – 120 undergraduate and 1 200 postgraduate students in the Postgraduate Diploma in Financial Planning Law and the Advanced Postgraduate Diploma in Financial Planning Law respectively – are enrolled at the centre. Undergraduate students attend weekly contact sessions while the postgraduate students all study electronically through distance education.

According to Mr Rudolf Bitzer of Bitzer Design Studio, one of the two architecture firms involved in the development of the building, the new building was planned in order to to make provision for future extensions. “The opportunity for the centre to function independently was important from the beginning and facilities had to be positioned in such a way that the lecture hall and committee room could be hired out commercially when lectures were not being presented.

“The building consists of a large reception venue, which gives access to a lecture hall (which can be subdivided), a committee room, public amenities and a reception counter. The centre will present about ten lectures annually in its own building and the lecture hall can accommodate 80 students. Exams will also be written in the venue,” said Mr Bitzer.

The usable inside area of the building totals 827 square metres.

The staff function in their own section of the building, with the offices arranged around a courtyard. Security access makes it a secure environment. In addition, staff have access to a staff room with a service hatch to the reception room, reception counter, personal assistant’s office, nine individual offices and a large open plan office, a storeroom, a cleaners’ room and facilities for staff.

“With the design, an attempt was made to make the building stand comfortably in the landscape without disappearing into the natural landscape. It is an unpretentious building, which seeks to provide well articulated architecture,” said Mr Bitzer.

The architecture firms involved are Bitzer Design Studio and Roodt Architects.

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