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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Open Day attracts thousands
2012-05-02

 

Campus was abuzz with prospective students and their parents finding out what Kovsies has to offer.
Photo: Kaleidoscope Studios
1 May 2012

“It is easier to pass Grade 12 today because we don’t have a standard. However, at the University of the Free State, standards are important.”

This was Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS’ message when he addressed a packed Callie Human Centre on the Bloemfontein Campus during this year’s Open Day.

“This university is the jewel of the country. Here at Kovsies we take academic standards seriously. You must know who you are in a place where academic standards are extremely important. Anyone can obtain a degree, but here you can get more than a degree. You get an education,” he said to the more than 5 000 learners and parents from across the country.

“It is not only important that you study here in South Africa, but also in other countries. That is why our students study all over the world. You must think out of your comfort zone, have a big heart, achieve great heights and show everyone that you are a Kovsie.

But, it is not all about studying – it is also about being human and reaching out to others. When you come to this university, you will also do other things that will make you proud of being a Kovsie.

Quality looks for quality. Therefore, work hard and study hard because you need to be at a good university,” he said.

The programme consisted of, among others, a spectacular laser show, a performance by Bobby van Jaarsveld and special messages from DW Bester and Sannah Mokone, Rhodes Scholars currently studying at Oxford University in the United Kingdom.

In a pre-recorded message DW, a Ph.D. student in Mathematical Statistics, encouraged prospective students to work hard and persevere. Sannah, doing a Master’s degree in African Studies, said she believes in the future of the African continent. “I believe in our future students and know you can make it.”

Prof. Jansen also introduced some of the university’s recent student achievers such as Jurie Swart, regional winner of the Corobrik Architectural Student of the Year Award; Farzana Samuel, named by the Association of South African Quantity Surveyors (ASAQS) as the most outstanding student in quantity surveying for 2012; and Sibusiso Tshabalala, one of Google’s Top 10 Young Minds.

Richard Chemaly, President of the Central Student Representative Council (CSRC), said that, by coming to Kovsies, prospective students would become the best person they can be. “We have over 70 student organisations to help you take part in student life activities. So, make use of these opportunities,” he said.

The programme concluded with an introduction to the seven faculties by the respective deans.

The estimated 7 000 prospective students and their parents also had the opportunity to visit faculties and the stalls of residences.
 

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