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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Eusibius McKaiser gives first talk on new book at Kovsies
2012-05-09

 

Eusibius McKaiser
Photo: Johan Roux
9 May 2012

Students and staff from our university got the first glimpse of political and social commentator Eusibius McKaiser’s new book, There is a Bantu in my bathroom, during a public lecture of the same title held by the author on the Bloemfontein Campus.

McKaiser told the audience that they were amongst the first people to get a preview of his book, a collection of essays on race, sexuality and politics.

His talk centred on domestic race relationships, posing the question whether it was acceptable to have racial preferences with regard to whom you live with. Recounting an incident he encountered while looking for a flat in Sandton, McKaiser said the country was still many kilometres away from the end-goal of non-racialism.

McKaiser, who hosted a weekly politics and morality show on Talk Radio 702, and is a weekly contributor to The New York Times, said the litmus test for non-racialism in South Africa was not what people utter in a public space, but rather what was said in private.

“We need to talk more about the domestic space. In public, we are very insincere and quick to preach non-racialism.”

Recounting conversations he had with Talk Radio 702 listeners on the incident, McKaiser said that preference about whom you live with was not specific to white people’s attitude. He said many of his black listeners also felt uncomfortable living with a white person. “The question is, ‘What do these preferences say about you? What does it say about where we are as a country and people’s commitment to non-racialism?’”

McKaiser was the guest of the International Institute for Studies in Race, Reconciliation and Social Justice.
 

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