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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

“Deploy your education and not connections,” Chancellor tells graduates
2012-05-16

 

Qwaqwa Autumn Graduation
Photo: Thabo Kessah
16 May 2012

Our Qwaqwa Campus conferred 424 degrees, diplomas and certificates at this year’s autumn graduation ceremony held on 12 May 2012.

Amongst the degrees conferred were two doctorates in Polymer Science, two Master’s of Arts in Geography and African Languages, respectively, five Master’s of Science degrees in Physics (3) and Polymer Science (2) and 37 honours degrees in Education, Zoology, Physics, Botany and Polymer Science.

In their congratulatory messages, both the Vice-Rector: Institutional Affairs, Prof. Teuns Verschoor, and the Chancellor, Dr Khotso Mokhele, challenged the graduates to start focusing their attention beyond their graduation on what they both referred to as “the real world”.

“Graduation ceremonies are a fantastic event, but you must never lose sight of appreciating the support given by those around you,” said Dr Mokhele.

“This hall was full of shouting and yes, you must bask in that glory, knowing that you have achieved part of your goals. Yes, this is your moment, so shine. You deserve it. You have earned it.”

“However, this noise also means you must go out there and face the real world. You are graduating in a model country on how people can reconcile, despite their painful and divided past. You deserve all the accolades, but that model country is disappearing before your eyes. How can you mess up what Mandela, Biko, Sobukwe, Nardine Gordimer lived and fought for? How can you mess up such a good thing?” Dr Mokhele asked of an attentive audience that included proud parents and siblings, as well as educators and learners from the Thabo Mofutsanyana District.

“Go out there and deploy your education and not your connections, as these are embedded in corruption. Go out there and help get rid of the patronage system where hard-workers are more likely to be constructively dismissed as they stand in the way of those with corrupt tendencies. Save this country from becoming another Zimbabwe. Let us do whatever it takes to save this country. Let these matriculants who are here today want to walk that red carpet with pride in the next few years,”,said Dr Mokhele.

Dignitaries in attendance included the former Chief Minister of the former Qwaqwa homeland, Dr T K Mopeli; the Executive Mayor of the Dihlabeng Local Municipality, Councillor Tjhetane Mofokeng; Dr SWF Moloi (Thabo Mofutsanyana Education District) and representatives from various government departments.
 

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