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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Three more Kovsie staff members involved in Olympic Games

2012-05-30

Dr Derik Coetzee
Photo: Supplied
30 May 2012

The South African men’s hockey team will practice on our Bloemfontein Campus from 28 May to 8 June 2012, and the team count on the assistance of three Kovsies to prepare them for the Olympic Games taking place in London later this year.

Dr Derik Coetzee, senior lecturer in the Department of Exercise and Sport Science and Head of our High Performance Centre, has been appointed conditioning coach of the team. He will be assisted by Colleen Jones and Riaan Schoeman, also from this department.

The UFS team and Mr Gregg Clark, the team’s coach, will work out a periodisation programme for the team, which will continue until the hockey finals at the Olympic Games. The programme includes the correct exercises, volume, intensity and number of exercise sessions per week.

This is not the first time that Dr Coetzee has assisted sports teams to prepare for important events. In 2007, he was the conditioning coach of the Springbok rugby team that won the World Cup in France. He was also the conditioning coach of the under-21 Springbok team in 2002 that won the Junior World Cup Tournament.

Dr Coetzee says it is a challenge to ensure that the team performs well at the Olympic Games. “The joy on the faces of the coach and players when they qualified in Japan cannot be described because many people thought they would not qualify.”

With the addition of Dr Coetzee, Ms Jones and Mr Schoeman, a total of six staff members from the UFS will be involved with the Olympic Games and the Paralympic Games. The other three are:

Dr Louis Holtzhausen, Head of the university’s Department of Sports and Exercise Medicine, has been selected as team doctor for the more than 300 athletes that will represent South Africa at this year’s Olympic Games (in London).
Ms Ebeth Grobbelaar, Assistant Director of the South African Testing Laboratory for Prohibited Substances at the UFS, was invited to be involved in the Drugs Control Centre in the unit against prohibited substances which will test sportsmen and -women during the games.
Ms Hetsie Veitch, Head of the Unit for Students with Disabilities, has been invited to be a member of the Classification Panel at the final USA Paralympic athletics trials.

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