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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Seminar puts language issues under spotlight
2012-06-29

The South African Languages Bill does not meet the Constitution’s requirements and is not doing much to curb English monolingualism.

This viewpoint of a number of critics was discussed at a language seminar at the University of the Free State (UFS) this week.

The Faculty of the Humanities at the UFS presented the seminar on the Bloemfontein Campus, where interested parties could discuss issues and developments relating to the South African Languages Bill.

The seminar formed part of the combined annual conference of the South African Applied Linguistics Association, the Linguistic Society of Southern Africa and the South African Association for Language Teachers.

At the conference, the rich diversity of language and also the complexity of language in South Africa was recognised.

The latest South African Languages Bill has attracted much interest and varied viewpoints this past year.

One of the most significant - and also the most controversial - suggestion of the present bill is to extend the present bi-language obligation to a four-language obligation, which implies that at least one African language is added to the present formula.

Furthermore, there are other important stipulations regarding the establishment of language units that will have implications for the public service, and specifically, for language practitioners.

Prof. Koos Malan, a Constitutional Law expert from the University of Pretoria, speaking during a discussion session, said: “Language determination in constitutions and language legislation are indications of the official ideology towards dealing with language and cultural diversity in the specific state. The ideology can range from the support of multilingualism – at the one extreme – to the other extreme, where only one language will get preference as the official language.”

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