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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New generation must take South Africa into the Promised Land
2012-07-23

 

Prof. Somadoda Fikeni talks about Reconciliation and Social Justice on Nelson Mandela Day.
Photo: Johan Roux
18 July 2012

 

Former President Nelson Mandela was part of the Moses generation that took people out of bondage. What the country now needs is the Joshua generation that will take it into the promise land.

This is according to political analyst and public commentator, Prof. Somadoda Fikeni. He was speaking to staff and students participating in the Global Leadership Summit, which took place on the Bloemfontein Campus from 8-20 July 2012. Prof. Fikeni took part in a panel discussion on Justice and Reconciliation. He and other panellists observed that there were still many challenges facing reconciliation in South Africa.

Referring to controversial statements made by Helen Zille, Julius Malema and Pieter Mulder, Prof. Fikeni said public discourse had become toxic and that the country was faced by a leadership crisis.

Ms Yasmin Sooka, a former Commissioner of the Truth and Reconciliation Commission (TRC) and Executive Director of the Foundation for Human Rights South Africa, asked if reconciliation had not come at the expense of redress. She said that to date there had been no restitution.

Ms Lihlumelo Toyana, a post-graduate student at the university, was also part of the panel. She told the audience that 18 years into democracy, there are still people waiting for justice. Toyana said young people hoped to see change and wondered if South Africans would ever sit down and have dialogue about the past. “We need closure; we need to take the country forward.”

The other panelists were lawyer, politician and former Human Rights Commissioner Prof. Leon Wessels; a professor from the University of Cape Town’s Law Faculty, Prof. Jaco Barnard-Naude; and psychologist, Prof. Alain Tschudin.
 

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