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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Access meets quality in UFS-Varsity College partnership for law degree
2012-07-30

 
At the event were, from the left: Mr Frank Thompson, CEO of ADvTECH, Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS, and Prof. Johan Henning, Dean of the Faculty of Law at the UFS.
Photo: Johan Roux
30 July 2012

The University of the Free State (UFS) and Varsity College this week officially launched a partnership whereby the university’s Faculty of Law will offer a four-year Bachelor of Law qualification through the UFS School of Open Learning on eight Varsity College campuses nationwide. This new degree will be offered as early as 2013.

This is the fulfilment of a dream, said Prof. Johan Henning, Dean of the Faculty of Law at the university. He was one of the speakers at the event that was attended by staff members and management from the, Faculty of Law, the university’s South Campus, Varsity College and ADvTECH.

The UFS Faculty of Law is one of the oldest and most distinguished faculties of law in South Africa, and has a close association with several overseas universities which ensures that the institution is internationally recognised.

“I am very positive and enthusiastic about this new partnership. We want to make this an enriching experience for staff and students from both the university as well as Varsity College,” Prof. Henning said.

The CEO of ADvTECH, Mr Frank Thompson, said he is overjoyed about the project and its potential. Varsity College is a brand of the ADvTECH Group, a JSE listed company invested in human capital.

“This is a new beginning for Varsity College and the UFS. Learning together, the slogan for this project, is very appropriate. We are excited to add new students to the university and Varsity College’s line-up,” Mr Thompson said.

Varsity College is part of the Independent Institute of Education (IIE), the leading provider of private higher education in South Africa. According to Dr Felicity Coughlan, Director of the IIE, the partnership between the IIE and the university is an example of the potential that is inherent in public-private partnerships to increase the range of high quality options available to students.

Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS, who also was one of the speakers at this event, said with this partnership, students will get the best of both worlds in accessing higher education.

The Faculty of Law will ensure that students obtain both a thorough grounding in legal theory, as well as a solid practical foundation, and Varsity College, through a strong commitment to innovative teaching and learning, will empower more students to become legal graduates of the highest calibre. Thus, the innovative partnership between the UFS and Varsity College will produce a Bachelor of Law degree that is highly sought after in the legal profession.

This partnership is the first of its kind, paving the way for increased collaboration between public and private tertiary institutions to best serve the education sector and the future of graduates.

“This is what is possible when two dynamic partners like the university and Varsity College come together,” Prof. Jansen said.
 

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