Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Two of our academics contribute to a fascinating book
2012-08-11

Prof. Jo van As earlier this year with proofs of the book The Story of Life & the Environment: An African Perspective.
Photo: Leatitia Pienaar
10 August 2012

The planet has more species than ever before, but humans are responsible for the biggest mass extinction of all times. This is according to Prof. Jo van As, Head of the Department of Zoology and Entomology. He was speaking at the launch of the book The Story of Life & the Environment: An African Perspective.

The book was published by Random House Struik in July 2012 and is a sister publication of The Story of Earth & Life by Prof. Bruce Rubidge, which was published in 2005.

The Story of Life & the Environment: An African Perspective took five years to complete. Prof. Van As was the compiling author, with Prof. Johann du Preez, Head of Plant Sciences at our university, Prof. Leslie Brown of Unisa and Prof. Nico Smit of the North-West University as co-writers.

Prof. Van As said, “No other species has destroyed the earth as we have done. Biological diversity disappears at the rate of mass extinction. The effects of human activities on the biological diversity is bigger that the extinction of the dinosaurs.”

He, however, added that The Story of Life & the Environment: An African Perspective does not sketch a doomsday scenario. It has also a message of hope. Prof. Van As said it was good to see progress in conservation and care for the environment. Trans-frontier parks the size of some countries are a good example of work in this regard.

Mr Stephen Johnson, chairperson of the board of Random House Struik, said at the launch that the publishing house was proud to be associated with the impressive book. The publication will be a touchstone for thoughtful readers for a long time. It will also remain a general book for the public and learners on the topic. The content and design was done in such a way that the publication will be relevant to all audiences.

The Afrikaans version of the book, Die Verhaal van Lewe en die Omgewing, will be published soon.
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept