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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Moeletsi Mbeki discusses South Africa’s political economy

2012-08-17

At the guest lecture was, from the left: Johann Rossouw, lecturer in the Department of Philosophy, Mr. Moeletsi Mbeki, and Prof. Pieter Duvenage, Head of the Department of Philosophy.
Photo: Johan Roux
17 August 2012

South Africa’s ongoing problems do not have their origin in the apartheid dispensation but in the British colonial period. This is according to the well known businessman and political analyst, Mr Moeletsi Mbeki, who was speaking during a guest lecture at the University of the Free State.

Mr Mbeki said the high unemployment rate among Blacks arose from the destruction of the Black small farming class in the last third of the 19th century to provide cheap labour to the developing mining sector. He said the notorious Land Act of 1913 was not the root of Black people’s loss of land but merely the legal formalisation thereof. Mr Mbeki emphasised that as long as it was argued that South Africa’s problems arose during the apartheid dispensation, problems would remain unsolved.

Regarding South Africa’s future, Mr Mbeki argued that three issues in particular were important – South Africa’s industrialisation, which ground to a halt in the 1970s, should be revived; the large scale training of industrialists with special emphasis on mathematics, science and the broader education system; and post-nationalist politics, of which parties such as Zimbabwe’s MDC, Zambia’s MMF and Mauritius’s MMM were outstanding examples.

The guest lecture was presented by the Department of Philosophy. More than 200 people attended the lecture and participated enthusiastically in the question and answer session. Afterwards, Mr Mbeki said he was impressed with the high level of the questions asked by students, which he said gave him hope for South Africa’s future.

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