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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

‘Global financial crisis is far from over’
2012-09-09

At the lecture were, from the left: Dr Arno van Niekerk (Department of Economy), Dr Francois Strydom (Centre for Teaching and Learning), Dr Mallory du Plooy (UFS101), Ms Gill Marcus, Governor of the Reserve Bank, and Lauren Hing and Louise Strydom of the UFS101 office.
Photo: Leatitia Pienaar.
6 September 2012

The global financial crisis the world has been experiencing since 2008 is far from over. In fact, Gill Marcus, Governor of the South African Reserve Bank, expects it to last for the next five years. “It is the longest financial crisis in history,” she said.

Ms Marcus lectured in the new UFS101 course of the university. The course was implemented at the beginning of the year and is aimed at broadening the world for new first-year students. About 2 000 students are taking the course.

Ms Marcus brought globalisation home and explained how activities in the international area impact on the lives of South Africans. She said South Africa was not excluded from the effect of global crises. Ms Marcus also said that South Africa was one of only a few countries in the world not experiencing a banking crisis due to strict controls in place, but more could be done.

“The big question is how to make sure that the South African banking system stays sound,” she said.

On a question about the debt of South Africans, she said it was important for South Africans to live within their means. “If we want to afford our new development, we need a savings percentage of 25 percent.” South Africa needs foreign capital investment to supplement the low local savings.

“It is difficult to resist all aspects of globalisation. Some can be to our advantage, but the others pose tremendous challenges.”

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