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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New facility helps with better clinical training
2012-09-06

 
The new Authentic Learning Space at the School of Nursing allows students to practice very important skills in their state-of-the-art patient simulation rooms.
Photo: Supplied.
4 September 2012

When you visit the School of Nursing at the Bloemfontein Campus of the University of the Free State (UFS), you will be alarmed by all the casualties and patients being treated here daily.

There are patients with serious penetration wounds, as well as open and laceration wounds which could be fatal if not attended to urgently.

In one ward a child is being treated for breathing difficulties and in the emergency ward a patient who suffered a heart attack has just been rushed in.

At the end of the session students pack up their textbooks and the ‘patients’ are re-programmed and prepared for the next group of nursing students to practice their clinical skills.

The School of Nursing recently had the official opening for their Authentic Learning Space where they showcased their state-of-the-art patient simulation rooms.

In each of the many examining rooms as well as in the high-care rooms there are simulation mannequins that can be programmed for certain medical conditions or for medical emergencies.

Speaking at the opening of the Authentic Learning Space, Prof. Driekie Hay, Vice-Rector: Academic, said universities are often accused of not preparing students adequately for their careers.

“We know students learn better by interaction. With access to authentic learning spaces, students are able to gain a deeper sense of a discipline and they can begin to grasp the unwritten knowledge of practice that is often used on a daily basis.”

 

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