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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Rose Ball promises to be an unforgettable experience

2005-09-08

On Saturday 15 of October 2005, the Department of Paediatrics and Child Health at the University of the Free State (UFS) in collaboration with Medi-Clinic, are hosting a Rose Ball in aid of children and babies with serious diseases and special needs.

The Bloemfontein public should get ready for one of the most magnificent events ever held in the city.

The Rose Ball promises to offer an evening of glamour, elegance and beauty which will make it an unforgettable and unique event. The Department aims to make the Rose Ball an annual event to which the Bloemfontein public can look forward to with expectation.

“Excellent food and wine, a 35 man symphony orchestra and of course a magical setting awaits those who attend the Rose Ball. We will do everything possible to make guests feel special, so that they return to the Rose Ball year after year. In this way, we can ensure an annual income from this event for children and babies who are very ill and need specialised care,” said Prof. André Venter, Head of the Department of Paediatrics and Child Health.

The Department of Paediatrics and Child Health at the UFS is responsible for the tertiary care, that is highly specialised care, of around 1 000 000 children in the Free State, Northern Cape, North-West, Eastern Cape and Lesotho. Approximately 13 000 out-patients are treated at the Universitas and Pelonomi Hospitals annually. Children who suffer from cancer, heart disease, neurological disease and endocrinological and gastro-enterological conditions are treated. The Department is also responsible for children who need intensive care and children with contagious diseases. In addition, there is a large neonatal unit where prematurely born babies are treated.

The level of health care needed to treat these children and babies, necessitate highly specialised equipment and knowledge. However, it is not always possible to replace or upgrade equipment, due to the lack of much-needed funds. That is why a fund was created within the Department to satisfy the need for funds. The Rose Ball promises to eventually give a vital boost to the fund that will go a long way toward providing in the special healthcare needs of these patients.

The Rose Ball is made possible thanks to the support of Medi-Clinic.

“Medi-Clinic is honoured to be involved in this great effort and in this way take hands with the Department of Paediatrics and Child Health at the UFS. There are so many children with life-threatening diseases today and we cannot afford to be uninvolved in any effort to make life better and easier for these children. We at Medi-Clinic, as a private sector company, look forward to establishing a long-term commitment with the Department of Paediatrics and Child Health,” said Mr Sakkie van der Merwe, Hospital Manager of Bloemfontein Medi-Clinic.

Only a limited number of tables are still available for the Rose Ball. Tickets cost R500 per person or R5 000 per table of 10 people.

Those who are interested can contact Ms Ilse Olivier at 051-4012415 or Ms Adele van Aswegen at 051-4013535 for more information.

Media release
Issued by:  Lacea Loader
   Media Representative
   Tel: (051) 401-2584
   Cell: 083 645 2454
   E-mail: loaderl.stg@mail.uovs.ac.za
8 September 2005

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