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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Read a book SA encourages South Africans to read one book a month

2012-09-20

Campus Principal Dr Elias Malete on the left and Tebogo Ditshego's. With them are Betsy Eister, UFS Director: Library and Information Services and Mathene Mahanke from the Department of Sport, Arts, Culture and Recreation.
20 September 2012

'Read a book SA's" objective is to bring reading into the everyday lives of South Africans. Speaking at Writers’ Day on the Qwaqwa Campus of the University of the Free State last Thursday, Ditshego said reading was essential. “Of all the skills that anyone can ever have, reading is the most fundamental of them all. It improves one's attention, confidence and discipline, amongst others.”

Ditshego asked why South Africa is presently faced with a 25,2% unemployment rate compared to Germany's 6-8%, despite South Africa having more and better natural resources. The answer, according to him, rests with lack of knowledge and critical skills in South Africans.

“Out of 144 countries, South Africa is ranked 133th in as far as the delivery of quality education is concerned. The reason for this is that South Africans lack knowledge, as they do not read enough. Most South Africans read for information, which is different from knowledge,” Ditshego argued.

In his welcoming remarks, Campus Principal Dr Elias Malete challenged authors to continue reminding society of their responsibilities.

“It is also your duty and responsibility to teach diplomacy lessons, to teach about effective leadership that is accountable, fair and transparent,” said Dr Malete.

Amongst the established authors who shared their wisdom with budding writers was Dr KPD Maphalla, a Sesotho literature guru and custodian of Sesotho language and culture. UFS students and learners from Sekgutlong and Tiisetsang secondary schools had the opportunity to showcase their writing skills. They also received expert advice on manuscript development and publishing from Mathene Mahanke from the Free State's Department of Sport, Arts, Culture and Recreation.

The annual Writers' Day is a joint venture of the Campus Principal and the Library and Information Services (LIS).

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