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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS academic speaks on Islamic terrorism
2012-09-12

 
 Prof. Hussein Solomon

Senior Professor Hussein Solomon from the Department of Political Studies and Governance at the University of the Free State (UFS) says it is imperative that we understand how ordinary Muslims are socialised, violently radicalised and primed to engage in acts of terror.

He was speaking at the Inter Religion Forum in the Faculty of Theology on the topic, “The rise of Islamist fundamentalist thought”.

According to Prof. Solomon, “The war on terror is truly a struggle between competing ideologies, after all, before a suicide bomber detonates his/her vest he/she must be ideologically indoctrinated to believe that what he/she is doing is the ‘right’ thing both in terms of the act and target.” Prof. Hussein, however, assured that the pure teaching of Islamic is not in favour of terrorism and killing.

Most of the twentieth century witnessed an ideological struggle between freedom and democracy. According to Prof. Solomon, “democracy” won that struggle. “The ideological struggle between freedom and authoritarianism is, however, far from over and thus we witness a clash of two competing ideologies across the globe,” he said.

He added that this is not an inter-civilizational conflict. “It rather is occurring within Muslim societies and between radical Islamists and the West.”

“A major battle is taking place in Islam between moderates, who in my view are the real Muslims, and the Islamo-fascists. Non-Muslims cannot simply regard this battle as an internal struggle. They need to support the moderate Muslim actively.”

“Should moderate Muslims lose this struggle, a clash of civilisations will become inevitable and the future will resemble a world of a war of all against all,” Prof. Solomon said.
 

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