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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Afrikaans place names were not only given by Afrikaner people, says professor.

2012-09-25

Prof. Peter Raper delivering his lecture on South African place names.
25 September 2012

Prof. Peter Raper, honorary professor at the Department of Linguistics and Language Practice, delivered a public lecture in Clarens earlier this month. The theme of the lecture was “From Stone Age to GPS: The fourth edition of the South African Place Names Dictionary”.

Prof. Raper shared the historical development of the project as well as the challenges and other interesting observations associated with the topic. He elaborated on the dramatic change in the focus of his research on place names in South Africa.

It was previously assumed that all of the Afrikaans place names were given by the Afrikaner people and that changing these place names was consistent with the mandate of the South African Geographical Names Council (SAGNC) to transform place names. Prof. Raper said more in-depth research revealed that a significant number of place names are actually translations of original San names – into Afrikaans, Khoi and the Bantu languages. He told the audience that given the constitutional stipulation that no cultural group’s heritage may be removed, this discovery calls into the question the modus operandi of the SAGNC.

Prof. Raper’s lecture was part of the conference programme of the Third International MIDP IV Symposium that took place on the Qwaqwa campus. The MIDP (Multilingual Information Development Programme) is a project sponsored by the Province of Antwerp. The theme for this year’s symposium was “Multilingualism for Empowerment” and was presented in collaboration with the University of Antwerp.

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