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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Department of Political Studies and Governance involved in regional seminar on peace and security in Southern Africa
2012-09-26

Attending the Lusaka seminar was from the left: Prof. Hussein Solomon; Prof. Virgil Hawkins from Osaka University and main organiser of the seminar; and Prof. Theo Neethling.
26 September 2012

Two staff members from the Department of Political Studies and Governance, Prof. Hussein Solomon and Prof. Theo Neethling, were recently invited by the Osaka University in Japan to participate in a regional seminar in Lusaka, Zambia, on multinational peacekeeping and peace enforcement in Southern Africa.

The seminar was organised by the Southern African Centre for Collaboration on Peace and Security funded by the Japan Society for the Promotion of Science. Prof. Solomon presented a paper on the establishment of the Southern African contingent of the African Union’s African Standby Force, while Prof. Neethling presented his paper on United Nations peacekeeping operations in the war-ravaged eastern parts of the Democratic Republic of Congo.

The participation of Prof. Solomon, Senior Professor, and Prof. Neethling, Head of the Department of Political Studies and Governance, comes from a cooperation agreement between Osaka University’s School for International Public Policy (OSIPP) and the Faculty of Humanities at the University of the Free State. The agreement covers issues like joint collaboration projects, the exchange of staff and senior students and joint conferences. One of the key joint areas lay in the Southern African Centre for Peace and Security Studies, a consortium of several Southern African universities with Osaka University and the University of the Free State as its key pillars.

Other universities include the University of Zambia, Zambian Open University, University of Dar es Salaam, Mozambique-Tanzania Centre for Foreign Relations. Academics from other universities in the region, like Nzuzu University in Malawi, University of Botswana, University of South Africa, Stellenbosch University, University of Zimbabwe, are all in the network.

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