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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof. Willem Boshoff joins Department of Fine Arts
2012-10-05

Prof. Willem Boshoff

Prof. Willem Boshoff, one of South Africa’s most established artists, has joined the Department of Fine Arts as a mentor for postgraduate students. Prof. Boshoff, whose work has been shown extensively in South Africa and internationally, will serve as mentor and resident artist in the department.

Prof. Boshoff made his mark at the university in 2011 when his Thinking Stone sculpture, one of sixteen artworks commissioned by the Sculpture-on-Campus project, was installed near the Main Building. The "Black Belfast " granite stone, situated next to the H vd Merwe Scholtz Hall, weighs approximately 20 ton and, to date,is the largest of the artworks funded by the National Lottery Distribution Trust fund.

Mr Ben Botma, Head of the Department of Fine Arts, says Prof. Boshoff, who is based in Gauteng, will work on the Bloemfontein Campus for certain months of the year. “As an artist he is extremely productive and has an impressive international exhibition programme. As a result he has a good overview of what happens in the most important museums and contemporary galleries. This information and insight can be shared with students with great success.”

Mr Botma says although the mentorship is aimed at postgraduate students, Prof. Boshoff’s presence and obsessive work habits will also motivate and inspire undergraduate students. “Willem is very popular as external examiner and moderator at other universities and he has a good perspective of what happens at the major universities”.
 

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