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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS Faculty of Law and Department of Health join hands to combat modern day slavery

2012-10-03

At this event, were from the left: Dr Adri Krieger and Dr Mariaan Kotze. Both are from the Department of Health: Directorate Forensic Services. Far right is Dr Beatri Kruger from the Unit for Children's Rights and the Department of Criminal and Medical Law at the UFS.
4 October 2012

Research and court cases confirm that the trade in people is a reality in South Africa. According to Dr Beatri Kruger from the Unit for Children's Rights and the Department of Criminal and Medical Law at the University of the Free State (UFS), complex challenges are faced in combating human trafficking. One of these challenges is a lack of knowledge of this crime and the difficulty in identifying trafficked victims.

To address the lack of knowledge, a number of discussions took place between Dr Kruger and delegates from the Department of Health.

A project has been initiated to address this problem in the public health sector. A need to raise awareness and provide training to medical practitioners to better understand human trafficking was identified. The most important aim of this initiative is to empower medical staff, to identify trafficked victims that visit hospitals and clinics countrywide and to also treat them appropriately in light of the severe trauma they have often been exposed to. The initiative will also empower medical practitioners to refer patients to other service providers such as social workers and psychologists.

The talks with medical practitioners from the Department of Health have led to training and awareness raising that will be provided at some of the local hospitals before the end of the year. Further training seminars are planned for medical practitioners, which will include a presentation by Dr Kruger on legal issues that are relevant for staff in the public health sector. The multidisciplinary cooperation that was established between representatives from the UFS Faculty of Law and the Department of Health has contributed substantially to a more effective response to human trafficking in South Africa.

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