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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Colloquium focuses on rural education
2012-10-10

Some of the international delegates during the second annual colloquium on rural education recently held at the Qwaqwa Campus.
10 October 2012

 The second edition of the Sustainable Rural Learning Ecologies (SuRLEc) Colloquium was held at the University of the Free State's Qwaqwa Campus this week. This three-day international event provided the Faculty of Education's postgraduate students with a platform to present their research and to learn from experienced researchers from all over the world.

In his opening address, the Faculty's Programme Head, Dr Dipane Hlalele, challenged all delegates to translate their research into achievable goals to address all the challenges facing rural education.

"Excellence in teaching and learning in a rural context remains a challenge for all sectors and levels of the education endeavour," Dr Hlalele said.

"Urban and metropolitan schools, colleges and universities may unintentionally structure their learning programmes in such a manner that they neglect rural attributes. This results in the marginalising of learners and students from rural environments. To complete the loop, these institutions are more likely to fail in preparing graduates for decisive contributions to sustainable rural learning ecologies," Dr Hlalele added.

The colloquium was officially opened by the Vice-Rector: External Relations, Dr Choice Makhetha, who highlighted the fact that the UFS was already doing its bit in levelling the learning playfields in higher education.

"We are aware that many of our students who come from disadvantaged backgrounds find it hard to cope at university. As a result, we are not waiting for them to come through to us. We are already in partnership with a number of schools where we help learners to improve their results," Dr Makhetha said.

The crucial role played by rural teachers was celebrated during a gala dinner to honour and acknowledge their efforts despite a myriad of daily challenges.

Ms Jabulile Mabaso (The Mills Primary Farm School) was honoured for 'Excellence in multi-grade teaching in Foundation and Intermediate phases'. Ms Rekha Mathew (Sibonakaliso Primary Farm School) and Mr Andries Motsoere (Tshebedisano Primary Farm School) were awarded for 'Excellence in managing multi-grade curriculum'.

The 2012 SuRLEc Honorary Award went to Ms Motshedisi Damane for her valuable contribution to the development of rural education in the Thabo Mofutsanyana Education District. Last year's recipient was the Dean of the Faculty of Education, Professor Dennis Francis.

Delegates and keynote speakers came from Thailand, Malaysia, the Unites States of America as well as the SADC countries of Botswana, Zimbabwe and Lesotho. South Africa was represented by the Universities of the North-West, Limpopo, KwaZulu-Natal and CUT, amongst others.

 

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