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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University hosts Mandela Rhodes scholars
2012-10-02

Kovsie Dux student and SRC member Tumelo Moreri (centre), with Danielle Bowler and Unnel-Teddy Ngoumandjoka, two of the Mandela Rhodes Scholars who attended a summit for past and current recipients of the prestigious bursary on the Bloemfontein Campus.
1 October 2012
Photo: Johan Roux

Some of Africa’s top young minds gathered at the University of the Free State to discuss new ways of thinking about education on the continent.

About 50 current and past recipients of the prestigious Mandela Rhodes Scholarship from across the continent gathered on the Bloemfontein Campus to attend the Community of Mandela Rhodes Scholars Summit from 29 September to 1 October 2012. The theme for the summit was Re-Imagining Education in Africa and recipients from South Africa, Kenya, Nigeria and Uganda attended.

Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university, addressed the Mandela Rhodes scholars and told them as Africa’s next generation of leaders they have to be courageous, caring and agents of change. “You cannot re-imagine education unless you have imaginative leaders”, he told them. Referring to leaders like Martin Luther King, Chief Albert Luthuli, Ghandi and Nelson Mandela, Prof. Jansen told them in order to lead, they should have the capacity for caring, contemplation, courage, change,contrition,conciliation and clarity.

Mandela Rhodes Scholar and Convener of the Summit, Andrew Gasnolar, said the insights gained will be utilised by recipients in their spaces. "A consistent element which cropped up was that our privilege requires us to do the right thing. Active citizenry is required in which we all actively take a part in the education situation - from adopting a student to adopting a school to taking up teaching."

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