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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Inspiration from an Olympic Champion for Spring graduandi
2012-09-20

Photo: Hannes Pieterse
20 September 2012

The guest list for the Spring Graduation ceremony of the University of the Free State included an Olympic gold medallist, a former Miss South Africa finalist and the Prime Minister of a neigbouring country.

The new graduates could draw inspiration from Olympic swimming champion Chad le Clos, who was the guest speaker at the event. Also attending was the Prime Minister of Lesotho, the Honourable Thomas Thabane, who came to watch his grandson graduating from Kovsies. Sharing a stage with Le Clos was Rolene Strauss, a medical student, who was among the top five contestants at last year’s Miss South Africa competition.

Le Clos, who became a national hero in July when he won a gold medal in the 200 m butterfly at the Olympic Games by beating American swimming legend Michael Phelps, told new graduates to strive for the impossible. Giving them insight into his remarkable achievement, Le Clos told them nobody had expected him to beat Michael Phelps. “Even I thought it was impossible to achieve. Always have a goal and work towards it,” he told them and said his ambition was to build up swimming in South Africa. Le Clos said he hoped that by 2016 there would be more swimmers making South Africa proud.

Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university, delivered an Olympic-inspired message. Quoting the motto of the modern Olympic Games, ‘faster, higher and stronger’, Prof. Jansen told the new graduates that they had to be better than those who came before them. “I expect my students in a troubled country to learn how to be different, faster, higher and stronger. Faster means efficiency; it means to be responsive to those in need."

Drawing lessons for the country from Le Clos' victory, Dr Khotso Mokhele, Chancellor of the University, told the graduates to choose optimism. Referring to the Marikana mine tragedy, Dr Mokhele said the country was far from taking the last stroke. “Even if it looks as if the curtain is down; remember that final stroke of Chad le Clos and how the great Michael Phelps was defeated.”
 

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