Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Charlotte Maxeke Memorial Lecture launches national Women’s Month Celebrations
2012-08-17

Free State Premier Ace Magashule with President Jacob Zuma during the Charlotte Maxeke Memorial Lecture held on the Bloemfontein Campus.
Photo: Stephen Collett
6 August 2012

 

“Mother of African Freedom, heroine, teacher, unifier and true revolutionary.”

That is how dignitaries such as President Jacob Zuma, African Union (AU) Commission Chairperson Dr Nkosazana Dlamini Zuma, Basic Education Minister Angie Motshekga and others described Charlotte Maxeke, the woman they came to celebrate at the University of the Free State on 4 August 2012.

President Zuma honoured the life of the ANC Women’s League stalwart in delivering the fifth annual Charlotte Maxeke Memorial Lecture. The event officially kicked off the national Women’s Month celebrations and thousands of people made their way to the Bloemfontein Campus to listen to the President’s address.

President Zuma told the audience in the Callie Human Centre that women activism had not started with the 1956 march to the Union Buildings – it began much earlier. He spoke about Charlotte Maxeke’s leading role in the landmark 1913 march against pass laws in Bloemfontein and said this had inspired bravery and enthusiasm in the hearts of many in the struggle.

“As a collective, we must emulate the contribution of Mama Maxeke. In her honour, we must continue to open new paths for women, enable them to break new ground in leadership." President Zuma said Charlotte Maxeke, who believed a woman’s place was everywhere, had to be smiling with regard to Dr Dlamini Zuma’s appointment as Chairperson of the AU Commission.

In her speech, Dr Dlamini Zuma encouraged women to embrace the African Decade of Women, saying it was their responsibility to define and implement the changes they want to see. “We should define for ourselves what this decade means, define that we want to do, the role we want to play and achieve during this decade.”

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept