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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Staff, students, learners and the public opened their hearts during R5 coin-laying ceremony
2012-07-17

Photo:  Sonia Small
18 July 2012

Amidst a festive atmosphere on the Red Square in front of the Main Building on the Bloemfontein Campus of the University of the Free State (UFS), students, staff, learners and members of the public came together to make their contribution to stop hunger.

In celebration of former president Nelson Mandela’s birthday, the university collected money and food in the form of a coin-laying ceremony, the packing of food parcels, and a message delivered by Emeritus Archbishop Desmond Tutu in aid of the university’s No Student Hungry (NSH) campaign and Bloemfontein Child Welfare.

Representatives from schools in Bloemfontein donated their R5 coins, together with university staff, students, members of the public, and employees of Pick n Pay Hyper. Money collected at the coin-laying ceremony will be shared between NSH and Bloemfontein Child Welfare.

According to Ms Grace Jansen and Ms Carin Buys, patrons of NSH, the more than R42 000 that was collected will be donated to Bloemfontein Child Welfare in an effort by NSH to give back to the community. “We are impressed by the number of people who showed up and by the fact that people opened their hearts and pockets to give,” said Ms Buys.

Thirty employees of Pick n Pay Hyper in Bloemfontein were also present and packed 1 833 food parcels (equivalent to 11 000 meals). This forms part of a Pick n Pay initiative in cooperation with Stop Hunger Now that is being held countrywide today.

In total, 88 000 meals will be distributed in six cities in South Africa today. The 11 000 meals in the Free State have been donated to the university and according to Ms Jansen a social worker at the UFS will distribute it to other needy students. These are students who do not receive bursaries from NSH at the moment. Every food parcel contains rice, dried vegetables, soya, and vitamin and mineral enriched powder.

The university was honoured to have Emeritus Archbishop Desmond Tutu as the speaker at the event. He attended a dialogue in the Series of Dialogue between Science and Society today at the university where he took part in a conversation with Profs. Mark Solms and Pumla Gobodo-Madikizela as part of the Global Leadership Summit.

He made a special appearance at the university’s Nelson Mandela Day festivities. His message was simple but inspiring: “Everyone has, just like Madiba, the capacity to change lives. I hope there are people present who can say that they want to improve someone else’s life. You have the chance to make South Africa a country where no one goes to bed hungry. Help us to make South Africa a country where we have compassion for each other and care for each other”.

The UFS would like to thank the following schools for their contributions: 

Grey Kollege Primêre Skool
Grey Kollege
St Michael's School for Girls
Hoërskool Jim Fouché
Hoërskool Fichardtpark
Hoërskool Sentraal
Navalsig High School
HTS Louis Botha
Eunice High School 


 

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