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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Number of NRF-rated researchers increases in 2012
2012-10-29

29 October 2012

Three researchers at the University of the Free State received B-ratings for 2013 from the National Research Foundation (NRF). Prof. Johan Henning, Dean of Law, obtained the highest rating in his field of mercantile law in South Africa, a B1.

Prof. Jackie Naudé from Classical and Near Eastern Studies and Prof. Dingie Janse van Rensburg, Professor Extraordinary at the Centre for Health Systems Research and Development, also obtained B3-ratings. Prof. Naudé is the first B-rated researcher in the Faculty of Humanities.
Prof. Helene Strauss obtained the highest rating (Y1) for a UFS young scholar in the Humanities.
In total, the NRF rated researchers at the UFS grew from 95 in 2011 to 109 in 2012, a growth of almost 15 percent.
The NRF ratings committee consist of three reviewers from South Africa and three from abroad. A rating is valid for six years and researchers must reapply for rating before the end of that period.
For a B1-rating all reviewers must be firmly convinced that the applicant enjoys considerable international recognition for the high quality of the researcher’s recent output, with some indicating that the researcher is a leading international scholar in a field. For a B3-rating most of the reviewers must be convinced that the researcher enjoys international recognition for the high quality and impact of the research.
Prof. Jonathan Jansen, Vice-Chancellor and Rector, said in the UFS Research Report “The UFS now has among the highest number of NRF-rated scientists per size of the academic faculty and we have seen the productivity graph bear witness to a record growth in our funded research outputs; we have won our first-ever NRF/DST Research Chairs. In each of these achievements, the excellence we seek comes with and through the diversity we celebrate.”
More ratings and renewals were expected by the time of Bult went to print.. More than 35 researchers applied for ratings or renewal of ratings.
  • Colleagues who were admitted to the prestigious Academy of Science of South Africa (ASSAf) are Profs. Pumla Gobodo-Madikizela, Driekie Hay, Heidi Hudson, Lodewyk Kock, Odireleng Ntwaeaborwa, Hugh Patterton, Ian Phimister and Melanie Walker. ASSAf was established in 1996 with the mission of using science for the benefit of society. New members are elected after nomination by four existing members (at least two of whom do so from personal knowledge of the candidate). ASSAf has some 350 members and represents South Africa in the international community of science academies.
  • Dr Marieka Gryzenhout of Plant Sciences became a member of South African Young Academy of Science (SAYAS). SAYAS celebrated its first year in 2012. It was launched as a means to enable South Africa’s young scientists to fully participate in locally and internationally relevant research and development agendas. Prof. Aldo Stroebel, Director: Internationalisation, is also a member of SAYAS.

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