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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Africa and her diaspora grace the Africa Century International Writers’ Conference

2012-10-30

30 October 2012

Programme (Pdf format)

The Africa Century International African Writers’ Conference, organised by the wRite associates, in partnership with the Department of Arts and Culture, the University of the Free State (UFS) and the SABC, will take place on the Bloemfontein Campus of the UFS from 7 to 10 November 2012.This four-day conference will culminate in the 2012 South African Literary Awards ceremony where winners will be honoured.

The conference is dedicated to the memory and contribution of its special advisor and inspiration, Zwelakhe Sisulu, who passed away in October 2012.

The conference has attracted an array of scholars and artists from around the continent. The African diaspora will be one of the main features of the programme. Keynote addresses, the presentation of papers, dance, visual art, comedy, disc jockeying will all feature the Diaspora.

“This event will also mark the 21st anniversary of the then-OAU (now-AU) declared International African Writers’ Day (i.e. 7th November). The theme of this is: From Resistance to Creative Mediation: Celebrating a Century of Writing and Literary Intellectuals’ Influence On The Liberation Struggles & Political Impact on Literary Discourse and Development”, said Raks Morakabe Seakhoa, Managing Director of the wRite associates and Project Director of the South African Literary Awards and the Africa Century International African Writers Conference.

The patrons of the Africa Century International African Writers’ Conference include; Prof. Kgositsile Keorapetse, Prof. Chinua Achebe, Dr Nadine Gordimer, DrWanguiwaGoro and Dr Hugh Masekela.

“This prospective historical gathering of authors, literary scholars and historians will, as the then-OAU’s Conference of African Ministers of Education and Culture (meeting in Coutonou, Benin, in 1991) resolved, ‘…afford the African people a moment of pause within which to reflect on the contribution of African Writers to the development of the Continent’ ”,Seakhoa added.

He said, “We are delighted at the growth of the prestigious South African Literary Awards, as they are now spreading their wings to inaugurate the Africa Century International African Writers’ Conference and opening up to the continent and Diaspora’s writers.”

Other highlights of this four-day programme include:

An evening with the National Poet Laureate: poetry reading by Prof. Keorapetse Kgositsile and guest poets
Nobel Laureate, Nadine Gordimer discusses her latest work, ‘No Time Like The Present’
Poetry, comedy and performances
Creative writing skills development programme, facilitated by: Prof.KeorapetseKgositsile, Mr Walter Chakela and Dr Oswald Mtshali
Tsebo-Lethabo Primary and High Schools programme
Books, art & crafts and clothing exhibitions and more

For more information,visit www.africacenturyconference.org or www.sala.org.za

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