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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Spotlight on Excellence in Teaching and Learning
2012-11-08

 

Dr Lynette van der Merwe and Mr Fred Mudanvanhu
Photo: Stephen Collett
08 November 2012

Dr Lynette van der Merwe from the Department of Basic Medical Sciences was announced as the winner of the Vice-Chancellor’s award for Teaching and Learning 2012. This award celebrates the excellent work done by academics in their classrooms. Mr Fred Mudanvanhu from the Computer Science and Informatics Department was named winner of the Excellence in Teaching and Learning award on the Qwaqwa Campus. They received their awards during the first Excellence in Teaching and Learning Week held on the Bloemfontein Campus from 29 October to 1 November 2012.

Hosted by the Centre for Teaching and Learning, the week was a showcase of scholarly teaching in various disciplines and innovation in teaching and learning practice. Some of the top academics at the university exhibited and presented their scholarly contributions in the form of presentations, short videos and electronic posters. This celebration of excellent work done by academics started on 24 October 2012, with the Excellence in Teaching and Learning Day on the Qwaqwa Campus.

Dr Francois Strydom, Director for the Centre for Teaching and Learning, said presentations made during Excellence in Teaching and Learning Week, especially those by the candidates for the Vice-Chancellor’s award for Teaching and Learning, demonstrated cutting edge, reflective scholarship.

He said Dr Van der Merwe’s innovative practises in teaching and learning stem from her Ph.D. research on Generation-Y learners and what their specific preferences are within the context of the Faculty of Health Sciences. “She illustrated how important it is for lecturers to reflect on the characteristics of the students that they are teaching to find the optimal balance between face-to-face interaction and the use of technology to engage the current generation.”

Mr Mudanvanhu was singled out for his research that contrasted the impact of different types of combinations of peer facilitated learning with the technology to improve students’ success.

Speaking at the teaching and learning awards function,Prof.Driekie Hay, Vice Rector:Academics, said the celebration of excellence indicates the pursuit towards developing the next generation of teachers, doctors, architects, scientists and researchers, to name a few. “The graduate that we educate today is the next president, the next Nobel prize winner or your grandchildren’s teacher.”
 

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