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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Nadine Gordimer lauds university for transformation
2012-11-09

Nadine Gordimer
Photo: Sonia Small
09 November 2012

Lecture (Pdf format)

Renowned writer and Nobel Prize winner Nadine Gordimer has lauded the university for its efforts at reconciliation, highlighting several initiatives the university has put in place over the last few years.

She delivered the inaugural Reconciliation Lecture on the Bloemfontein Campus, and was introduced as a “champion of human oneness” by Prof. Pumla Gobodo-Madikizela, Senior Research Professor on Trauma, Forgiveness and Reconciliation, who also referred to Gordimer as “the living expression of the power of critical consciousness”.

Gordimer praised the university by saying it was doing things in South Africa differently from what had been done during the country’s shameful past. In a message addressed at students, her lecture touched on topics of race, reconciliation, freedom of expression, education, inequality and poverty.

“Black and white – we have been conditioned; no, brain-washed, by legal and cultural and even religious, demeaning distinctions between race and colour. This university has discarded; is tackling these: an image breaking of false consciousness. We await your generation’s entry to public life, when you come out of the University of the Free State equipped to bring to us, along with your professional degrees, the way to function in a population as the human beings you have learnt to be at this university.”

The Nobel laureate also warned students of threats facing South Africa’s future.

“What is your reaction, then, to the Protection of State Information Act, the Secrecy Act that has been drop on our heads? The Secrecy Act means that we the people are not allowed to know the facts about our own country. Know how our society, our population is manoeuvred by those entrusted and empowered by our votes.”

The inaugural lecture was hosted by the Vice-Chancellor and Rector, prof. Jonathan Jansen, and the Rectorate, with the support of the Institute for Reconciliation and Social Justice and Prof. Gobodo-Madikizela.

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