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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Qwaqwa Campus Hosts a DSD Roadshow
2012-04-04

 

In front, from  the left, in front: Joe Mosuhli (DSD Provincial Office), Ms Maboe Grey Magaiza (Lecturer: Sociology), Ms SM Khupane (Thibella Marakabeng Traditional Council), Mr Mbulaheni Mulaudzi (DSD). At the back, from the left: Dr Malete, Dr Elsa Crause (Departmental Head: Sociology), Chief Mahase (Phomolong Traditional Council), Mrs Sadi Luka (DSD), Chief QD Moloi (Makgolokweng Traditional Council), Chief Sekonyela (Thibella Traditional Council), Ms Mpontseng Kumeke (DSD) and Mrs Malikoankoetla Tsosane (Matsieng Traditional Council).

The National Department of Social Development (DSD) and the Free State Department of Social Development, in collaboration with the Qwaqwa Campus of the University of the Free State, hosted a road show on the professionalisation of Community Development Practice yesterday.

This inaugural road show was aimed at conceptualising and soliciting stakeholder buy-in in the new Community Development Qualification Framework, which was jointly developed by the department and the South African Qualifications Authority (SAQA). The road show also briefed stakeholders on the Recognition of Prior Learning (RPL) pilot project that will integrate the current community development workforce into the national qualification framework. Stakeholders were also briefed on the professionalisation process and were given a platform on which to talk about related issues. This included the formation of a community development association, a unified professional body and eventually, the formation of an independent statutory council.

In his welcoming remarks, Campus Principal Dr Elias Malete said that the envisaged programme of professionalising community development practice would address the local needs and bring vibrancy to affected communities. “The programme will definitely help in revitalizing our campus and the community we serve,” said Dr Malete. He was referring to the Qwaqwa Campus Revitalisation Plan. “Among the plans we have is the introduction of the four year Bachelor of Community Development degree. We are confident that our proposal will be received favourably and that we will offer this qualification from 2013,” Dr Malete said to applause from the invited guests and community members.

Talking on behalf of the provincial Department of Social Development was the department's head, Me Matlhogonolo Maboe, who emphasised the fact that large segments of communities were entirely dependent on the community development sector for their daily survival. “In professionalising the sector, we would be building vibrant rural communities and repositioning them to be better equipped in addressing what President Zuma referred to as the ‘triple challenge of unemployment, poverty and inequality’ in his State of the Nation address in February”, said Me Maboe.

Traditional leaders from the Qwaqwa area, national and provincial departmental officials as well as students and staff of the UFS attended the road show.
 

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