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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS Debate Society prepares for three major tournaments
2012-11-20

Preparing for the Berlin Championships are, from the left: Richard Chemaly, Zola Valashiya, Ros Limbo and Nkosi Mangali.
Photo: Linda Fekisi
20 November 2012

The UFS Debate Society will be taking on three major projects during the holidays. The month of December will be filled with activities for the team, with members taking trips to Grahamstown, Pretoria and Berlin, Germany to showcase their debating skills.

Their first project is a coaching session in collaboration with the Free State Schools Debating Board. The team will be coaching the provincial school teams and accompanying them to Grahamstown where they will compete in the National Schools Debating Championships in early December.

At around the same time, members will also attend the Pan African Universities Debating Championships that will be held in Pretoria. The PAN African Championship, which the team won in 2009, has expanded over the years and now also includes participants from Australia and the United States of America.
Towards the end of December, four members of the team will be heading to Berlin, Germany to compete in the World Universities Debating Championships. Ros Limbo, Nkosi Mangali, Richard Chemaly and Zola Valashiya will represent the university.

Zola, who is currently the chairperson of the debating society, has been part of the team since 2008. He describes being part of the teams as, “a growing experience. I have learnt a lot, especially how to be a critical thinker”. He was ranked among the top ten speakers in the English First Language division during the Kgorong 2012 National Universities Debating Championships earlier this year. Zola says the team’s goal is to gain as much experience as possible in order to offer training. They are looking at forming strong relations with various other debate societies across the country.
 

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