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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS confers honorary doctorate on one of the world’s foremost academics

2012-11-26

Prof. Martha Nussbaum
Photo: Supplied
26 November 2012

The University of the Free State (UFS) will confer three honorary doctorates at the Summer graduation ceremony on 6 December 2012. One of the world’s foremost philosophers is among those to be honoured. Prof. Martha Nussbaum, described by The New York Times as “one of the most prominent female philosophers in America”, will be honoured with a D.Litt. degree in the Faculty of Humanities. Judge F.D.J. Brand, a former Constitutional Court judge, and Prof. Otto Walter Prozesky, one of the country’s foremost medical researchers, will also receive honorary doctorates.

Prof. Nussbaum, who has honorary doctorates from 40 colleges and universities in America, Canada, Asia and Europe, is recognised for her intellectual and public contribution to human development. She is the Ernst Freund Distinguished Service Professor of Law and Ethics at the University of Chicago and an active member of the American Philosophy Association. Prof. Nussbaum is well-known and respected as a public intellectual and is considered to be one of the most prominent philosophers in the world.

Prof. Prozesky is to be honoured for the important role that he played in the field of medical research, especially as the President of the Medical Research Council and as researcher/educator in the field of virology and HIV/Aids. He is to receive an honorary degree in Medicine in the Faculty of Health Sciences.

Judge Brand, Extraordinary Professor in Private Law in the Faculty of Law at the UFS, is to receive a Doctor Legum degree in recognition of his considerable contribution to the legal science. More than 120 of his judgments are reported in South African legal reports. A review of recent South African legal journals (over the past five years) shows that reference is made to his judgments in at least 30 articles and case discussions.

The Summer graduation ceremony will be held in the Callie Human Centre on the Bloemfontein Campus and will take place in two ceremonies. At 10:15, master’s degrees and doctorates will be awarded, and at 15:15 qualifications will be awarded in a combined graduation ceremony of the Faculty of Health Sciences and the School of Open Learning.

Prof. Martha Nussbaum will lead a conversation with members of the public and the campus community on 7 December 2012. On 8 December 2012, she is the main speaker at the UFS’s conference on “Engaging the Other: Empathy and Breaking Transgenerational Cycles of Repetition” on the Bloemfontein Campus.

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