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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

International conference on breaking cycles of the past in societies affected by historical trauma
2012-12-06

 
28 November 2012

An interdisciplinary group of scholars, experts and practitioners from 24 countries around the world will gather at the University of the Free State (UFS) in Bloemfontein from 5 - 8 December 2012 for a conference on “Engaging the Other: Breaking Intergenerational Cycles of Repetition.”

The conference intends to open new avenues of inquiry into the trans-generational effects of trauma on communities that have experienced extreme violence.

One of the highlights of the conference is a presentation by Marguerite Barankitse, a survivor of the Rwandan genocide, on Thursday 6 December 2012. Marguerite has received several awards and distinctions for her work aimed at transforming the lives of Hutu and Tutsi children affected by war. Among these are the highly prestigious humanitarian prize, the Opus Prize, the UNESCO Prize, and the World's Children's Prize, also known as the ‘Nobel Prize’ for humanitarian work aimed at improving the lives of children and their chances of a better future.

On Saturday 8 December 2012 Prof. Martha Nussbaum, one of the world’s foremost philosophers, will deliver a keynote address on “Reconciliation: The political role of the Arts.” Prof. Nussbaum will receive a D.Litt. degree in the Faculty of Humanities from the UFS on 6 December 2012.

Other guests include Michael Lapsley, survivor of an apartheid bombing, Kimberlyn Leary, Associate Professor at Harvard Medical School, Dr Jean Decety, Irving B. Harris Professor at the University of Chicago and Dr Katerina Fotopoulou from the Institute of Cognitive Neuroscience at the University College in London.

One of the conference events entitled “South Africans speak about the crisis of moral leadership: A public dialogue” will be open to the public and presented in the Centenary Complex on Friday 7 December 2012 from 18:00-19:30. Participants in the public dialogue include some of South Africa’s most thoughtful social commentators and a community activist: Barney Pityana (Professor and Rector, College of Transfiguration); Prince Mashele (Director: Centre for Politics and Research); Pierre de Vos (Professor of Law, University of Cape Town); and Faeza Meyer (Chairperson: Tafelsig Residents Unite).

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