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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Two academics receive prestigious fellowship for leadership programme

2013-01-16

The University of the Free State (UFS) boasts two academics who received the HELM LEAD (Higher Education and Leadership Programme) Fellowship for 2013. Prof. Liezel Lues from the Department of Public Administration and Management and Prof. Liezel Herselman from the Department of Plant Sciences both received this prestigious fellowship.

After the nationwide nomination procedure – with a choice from 120 applications - Higher Education South Africa (HESA) awarded 25 placements in the programme. Candidates who were selected, had to be in middle-management positions within the university sector, had to have exceptional qualities, and had to exhibit management and leadership potential within their university.

This group will now undergo a number of modules in Higher Education, which will start during January in Cape Town. The aim of the programme, running between February 2013 and April 2013, is to provide learning opportunities for middle and senior managers to gain knowledge and skills, with a view to the successful navigation of the constant challenges of change and to interpret effectively the operational impact of internal and external drivers.

Modules include topics such as Academic Policy and Planning; Governance and Strategy; Systems Management; and Managing People and Change.

Prof. Lues stated that she applied for the programme because she strongly believes that an effective and vibrant public sector, and especially the role of female academics therein, will play a fundamental role in the transformation of the South African community towards a prosperous and tolerant society. “I believe the LEAD component of HESA will offer me the opportunity to enhance my knowledge and insight with regard to the socio-political environment and its impact on higher education institutions. The envisaged outcomes of the programme will also directly lead to the improvement of my leadership and management practices within the UFS’ Department of Public Administration and Management,” said Prof. Lues.

Prof. Herselman was appointed as Head of the Department of Plant Sciences, effective from 1 January 2013. She is very excited about this new position and said: “Although I am looking forward to the new challenge, I am aware of my lack of experience as a manager. The LEAD programme will provide me with the necessary skills and knowledge to succeed as Head of Department and will give me the opportunity to strengthen the Department of Plant Sciences and to make it a Department of international stature.”

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