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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Three OSM students selected for the 2013 World Youth Symphony Orchestra
2013-01-25


Carmi Nel

Elsabe Raath

Maja van Dyk

25 January 2013

Three students from the University of the Free State’s Odeion School of Music (OSM) have proved their mettle. Carmi Viljoen (violin), Elsabé Raath (viola) and Maja van Dyk (viola), have been accepted into the prestigious World Youth Orchestra – an orchestra known worldwide for its quality and the prix de corps itadvances between nations.

Musica Europa, an Italian cultural association, founded the World Youth Orchestra (WYO) in its present guise in 2001. It has close ties with UNICEF and its mission is to combine music with social activities from cultures all over to world in order to enrich the cultural life of all.

Rigorous auditions are held which require applicants to upload video recordings onto a website (Vimeo). An international board of adjudicators subsequently listens to these recordings and select the best.The three OSM students were good enough to make the grade.

These three musicians are also members of the Free State Symphony Orchestra, as well as the MIAGI orchestra that toured Europe successfully last year. They are also outstanding chamber musicians. Carmi and Elsabé, as members of the Junior Odeion String Quartet, have shown that they are on par with international standards and have toured The Netherlands. In 2012, Maja van Dyk had been selected to perform as soloist with the National Youth String Orchestra under the baton of Swedish conductor and violinist, Fredrik Burstedt.

They first heard of the possibility of playing for the WYO through Anmari van der Westhuizen, lecturer at the OSM. Margarite Spies from the KZN Philharmonic Orchestra (KZNPO) had contacted her in search of worthy candidates. A scant three weeks later, they received the good news of their inclusion.

The orchestra, with representatives from five continents, will be touring South Africa this year and no less than nine South Africans have been included. The tour kicks off in Durban, followed by performances in East London, Plettenberg Bay, George, Knysna, Stellenbosch, with a grand finale in the Cape Town City Hall.

Works that will be performed include ‘’Romeo and Juliet’’ by Prokofiev, the irrepressible “Carnival Overture” by Dvorák, Barber’s ‘’Adagio for Strings’’ and part of Mahler’s majestic Fifth Symphony, all under the baton of the dynamic Josep Vicent.

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