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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Multimillion rand donation to boost UFS schools
2013-02-05

At the launch were Dr Cobus van Breda, Director of the Science-for-the- Future Unit at the UFS, Mr Makhetha Botsane from the Free State Department of Education Mrs. Elizna Prinsloo, Programme Manager of the Family Maths and Family Science project and Mr Graham McCulloch, Free State representative of the Ilima Trust.
Photo: Kelly Abrahams
05 February 2013

The University of the Free State’s UFS) Family Maths and Family Science project has received a R1 million sponsorship from Old Mutual for 2013. This is a three-year project whereby the university’s School of Open Learning aims to demystify mathematics and science in the early school years, as stated in their mission. The launching ceremony took place on 1 February 2013 at the UFS Campus.

The sponsorship was made available by Old Mutual, but will be managed by the project management group, Ilima Trust.

The UFS received R30 million altogether from Old Mutual for the use on various projects.

Except for the Family Maths and Family Science project, the Schools make over project and the Internet Broadcasting Programme will also benefit from this donation.

“Ilima has a hands-on relationship with different projects and is the public face for the FM & FS sponsorship,” said Mr Graham McCulloch, Ilima Trust representative for the Free State.

“Today is the first step on the long road to improving math and science in the country,” McCulloch said.

Dr Cobus van Breda, Director of the Science-for-the-Future Unit  says the Family Math and Family Science Project makes science and math accessible to children and their parents in the early years, with the aim of developing positive attitudes towards these often difficult school subject.

“This project aims to empower educators, parents and student educators by iving support and training in hands-on teaching methodologies.”

Learners, educators and parents from 18 schools in Thaba Nchu and Botshabelo will benefit from this project. Teachers will receive training at the UFS and then return to their community to train parents and to teach learners. Teachers will also receive activity material to use in classrooms.

“The selection of the 18 participating schools took place by identifying feeder schools of secondary schools from the UFS School Change Project, trying to create a whole-school development,” Van Breda said.

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