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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A Rag procession to remember
2013-02-06

Photo: Albert van Biljon
05 February 2013


   YouTube Video

A Rag procession to remember and one of the best in years. This was the opinion of many spectators at the Kovsies’ annual Rag procession on Saturday 2 February 2013. Large numbers of people came to watch the procession moving through the streets of Bloemfontein as students showed off their floats.

A festive atmosphere prevailed along the route and some people came prepared with camping chairs and picnic baskets.

The proceedings began with a morning procession to the Twin City shopping centre in Heidedal and the Kenilworth shopping centre in Mangaung. About 10 000 food parcels were handed out in the two suburbs, while the UFS Cultural Office and KovsieFM entertained the residents.

Prof. Jonathan Jansen, Vice-Chancellor and Rector, as well as members of the senior leadership, went along on the journey to the two suburbs. Dozens of children and adults were at the Twin City shopping centre where hundreds of balloons were released. Kovsie staff, students and members of the SRC at the Bloemfontein Campus met with members of the community and helped to hand out food parcels.

The main procession left from the Bloemfontein Campus at 18:00 and proceeded to the Old Grey’s sports grounds for the Rag concert. Rag-goers were entertained by the music group Mi Casa, the singing duo and twin brothers Locnville, as well as Bobby van Jaarsveld. People were also treated to a fireworks display.

The float of the residences Karee, Soetdoring and Imperium was announced as the winning float.

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