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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First-year students welcomed into Kovsie Family
2013-01-23

 

New first-year students and their parents and guardians are welcomed on the Qwaqwa and Bloemfontein campuses.
Photo: Sonia Small
23 January 2013



   YouTube Video

They came from near and far. Some hail from Bloemfontein, others from as far away as Botswana but they all have one thing in common. They were here to start their first year as Kovsie students. Thousands of first-year students, along with parents and guardians, attended the first year welcoming on the Qwaqwa and Bloemfontein campuses on 18 and 19 January 2013 respectively.

“I do not care whether you come from the Free State or Zimbabwe or whether you are from Gauteng or Lesotho. I do not care if you speak Sesotho, Setswana or Afrikaans. What I care about is that you must understand that you are smarter than you think.”

This was the message from Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State (UFS), when he officially welcomed first year students to the Qwaqwa Campus. “At the UFS, we put emphasis on two very important projects - the academic and human projects”, said Prof Jansen.

“The academic project is about you excelling academically as a student. It is about being the best you can be in your chosen field of study. All of you should strive to be like Zandile, a young girl from Umlazi who, despite her poverty and challenging conditions at home, went on to attain seven distinctions in her 2012 matric results”, said Prof Jansen. He was referring to Zandile who he tracked down via Facebook to offer her a full bursary to study at the UFS. Zandile had appeared on SABC TV news, expressing her frustration at the lack of funds to continue her studies, despite her performance.

“The human project is about you loving those who are different from you, thus becoming better human beings,” Prof Jansen said.

Prof. Jansen echoed the same message on the Bloemfontein Campus the following day when he welcomed thousands of new students. These students, their parents and guardians packed the huge tent that was erected in the CR Swart parking area of the campus. Prof. Jansen welcomed students from the different faculties during four sessions. He told parents and students that the class of 2013 was the smartest class the university had had in its 109-year history.

Mr Rudi Buys, Dean of Students, informed them about the many opportunities that awaited them at Kovsies. These include programmes like the Leadership for Change Programme for first year students and the Stanford Sophomore College Program for second year students.

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