Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Prof. André Keet appointed to Ministerial Oversight Committee on Higher Education

2013-01-15

Prof. André Keet
Photo: Anja Aucamp
24 January 2013

Prof. André Keet, Director of the Institute for Reconciliation and Social Justice at the university, has been appointed as member of the Oversight Committee on the Transformation of South African Universities. He is one of seven committee members that were appointed by the Ministry of Higher Education and Training to monitor progress on transformation in public universities.

The committee will advise Dr Blade Nzimande, Minister of Higher Education and Training, on policy to combat racism, sexism and other forms of unfair discrimination in public higher education. The committee will also advise on the role of universities in promoting the development of a free, fair and non-discriminatory society beyond the world of the academia.

The senior leadership of the university has welcomed the appointment of Prof. Keet and said with his extensive experience as a former Commissioner on the Commission for Gender Equality and as the Director of the university's Institute for Reconciliation and Social Justice (which was formed as one of several initiatives taken by the senior leadership in the aftermath of the Reitz incident), Prof. Keet will be a valuable member of the committee.

"Prof. Keet has the experience and expertise to guard the autonomy and academic freedom of universities, thus avoiding this committee from becoming a political intervention in the affairs of the higher education sector," said Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university.

Honoured to be elected on the committee, Prof. Keet said he is ready to serve the national interest in the transformation of South African universities. "The appointment is also a compliment to the university and to its exceptional experience in the process of transformation."

Prof. Keet will serve on the committee for a period of three years. The other members of the committee are Prof. Malegapuru Makgoba, who will serve as chairperson, Dr Mvuyo Tom, Ms Nazeema Mohamed, Ms Zingiswa Losi, Mr Joe Mpisi and Prof. Shirley Walters.

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept